HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Difluoromethylene-1,2,3,4-tetrahydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl 4-difluoromethylene-3,4-dihydro-2H-quinoline-1-carbamate | HCID 67188534 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Difluoromethylene-1,2,3,4-tetrahydroquinoline | HCID 67188171 | 104.1% |
Reaction Steps
0.11 g of tert-butyl 4-difluoromethylene-3,4-dihydro-2H-quinoline-1-carbamate in 10 ml of dichloromethane is introduced into a round-bottomed flask equipped with a magnetic stirrer. 6 ml of a 4N solution of hydrochloric acid in dioxane are added. After stirring at ambient temperature for 6 h, the reaction medium is concentrated under vacuum. 0.07 g of 4-difluoromethylene-1,2,3,4-tetrahydroquinoline is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947834B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-c8c833fb7b7c40809e09c89c00275c69 |
| Source note | uspto-grants-2011_05 |