反应详情

0.07 g of (2,3-dihydrobenzo[1,4]oxazin-4-yl)[3-(4-fluoro-2-(trifluoromethyl)phenyl)-2,5-dihydropyrrol-1-yl]methanone in 3.57 ml of methanol is hydrogenated in an H-Cube device under hydrogen at atmospheric pressure with a cartridge of 100 mg of 10% palladium-on-charcoal. After concentrating to dryness, the crude reaction product obtained is chromatographed on silica gel, elution being carried out with a mixture of 5% of ethyl acetate in dichloromethane. 0.15 g of (2,3-dihydrobenzo[1,4]oxazin-4-yl)[3-(4-fluoro-2-(trifluoromethyl)phenyl)pyrrolidin-1-yl]methanone is obtained.

1. concentrationAfter concentrating to dryness
2. customthe crude reaction product
3. customobtained
4. customis chromatographed on silica gel, elution
5. additionbeing carried out with a mixture of 5% of ethyl acetate in dichloromethane