Hydrochloric Acid → 5-[{4-[(4-Butylphenyl)ethynyl]benzyl}(3-phenylpropyl)amino]-2-hydroxybenzoic acid, hydrochloride salt

Participants

Reaction Steps

To a solution of 6-[{4-[(4-butylphenyl)ethynyl]benzyl}(3-phenylpropyl)amino]-2,2-dimethyl-4H-1,3-benzodioxin-4-one (147 mg, 0.26 mmol) in MeOH/THF (9 ml, (2/1)) was added an aqueous solution of NaOH (0.3 mL, 5N). The reaction mixture was stirred at rt for 48 hrs. Then a solution of HCl in MeOH (2.5 mL, 1.25M) was added and the solvents were 5 removed under reduced pressure. The residue was taken up with water (5 mL), extracted with Et2O (2×5 mL) and the combined organic layers were dried over Na2SO4. The solvent was removed under reduced pressure. The residue was dissolved in a solution of HCl in Et2O (2 mL, 1N). Evaporation of the solvent gave 60 mg (32%) of the title compound as a brown foam. HPLC, Rt: 4.8 min (purity: 78.1%). LC/MS, M+(ESI): 518.4, M−(ESI): 516.3.

Provenance & Evidence