Hydrochloric Acid → (4-{[{4-[(4-Butylphenyl)ethynyl]benzyl}(ethylsulfonyl)amino]-methyl}phenoxy)acetic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl (4-{[{4-[(4-butylphenyl)ethynyl]benzyl}(ethylsulfonyl)amino]-methyl}phenoxy)acetate (7 mg, 0.013 mmol) in EtOH (1 mL) was added an aqueous solution of NaOH (20 μL, 5N). The reaction mixture was stirred at 70° C. for 2 hrs. Then an aqueous solution of HCl (1N) was added and extracted with EtOAc (2×). The combined organic layers were dried over Na2SO4 and the solvents were removed under reduced pressure to give 6 mg (90%) of the title compound as a pale yellow oil. HPLC, Rt: 5.0 min (purity: 75.0%). LC/MS, M+(ESI): 520.5, M−(ESI): 518.3.

Provenance & Evidence