Water → 4-(4-Butylphenylethynyl)benzoic acid

Participants

Reaction Steps

To a solution of methyl 4-[(4-butylphenyl)ethynyl]benzoate (23.0 g, 0.078 mol) in MeOH (200 ml) was added LiOH (3.6 g, 0.157 mol) followed by water (50 mL) and the reaction mixture was stirred for 5 hrs at rt. The solvents were removed under reduced pressure. The residue was acidified with an aqueous solution of HCl (1.5M) and a solid precipitated out. The precipitate was filtered and dried to yield 19.5 g (89%) of the title compound. 1H NMR (DMSO-d6) δ: 13.1 (brs, 1H), 7.96 (dd, J=1.6 and 6.7 Hz, 2H), 7.64 (d, J=6.8 Hz, 2H), 7.49 (d, J=8.1 Hz, 2H), 7.25 (d, J=8.2 Hz, 2H), 2.60 (t, J=7.5 Hz, 2H), 1.55 (m, 2H), 1.29 (m, 2H), 0.88 (t, J=7.3 Hz, 3H).

Provenance & Evidence