Hydrochloric Acid → 5-[{4-[(4-Butylphenyl)ethynyl]benzyl}(hexyl)amino]-2-fluorobenzoic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 5-[{4-[(4-butylphenyl)ethynyl]benzyl}(hexyl)amino]-2-fluoro-benzoate (454 mg, 0.91 mmol) in MeOH (40 mL) was added an aqueous solution of NaOH (2.7 mL, 1N). The reaction mixture was stirred at 50° C. for 36 hrs. Then an aqueous solution of HCl (5 mL, 1N) was added and the reaction mixture was poured into water (100 mL) and extracted with Et2O (200 mL+2×100 mL). The combined organic layers were dried over MgSO4 and the solvents were removed under reduced pressure to give 396 mg (90%) of the title compound as a beige powder. HPLC, Rt: 5.8 min (purity: 99.1%). LC/MS, M+(ESI): 486.1, M−(ESI): 484.0. 1H NMR (CDCl3) δ: 7.48 (d, J=8.3 Hz, 2H), 7.44 (d, J=8.3 Hz, 2H), 7.29 (dd, J=5.6, 3.3 Hz, 1H), 7.17 (m, 4H), 6.97 (dd, J=10.2, 9.0 Hz, 1H), 6.78 (ddd, J=9.0, 3.4, 3.3 Hz, 1H), 4.52 (s, 2H), 3.39 (t, J=7.6 Hz, 2H), 2.62 (t, J=7.6 Hz, 2H), 1.61 (m, 4H), 1.42-1.25 (m, 8H), 0.94 (t, J=7.3 Hz, 3H), 0.90 (t, J=6.8 Hz, 3H).

Provenance & Evidence