Hexanal → Methyl 2-fluoro-5-(hexyl[4-(phenylethynyl)benzyl]amino}benzoate

Participants

Reaction Steps

The title compound was prepared following the procedure described in Example 23 step b) using methyl 2-fluoro-5-{[4-(phenylethynyl)benzyl]amino}benzoate (213 mg, 0.59 mmol) and hexanal (Aldrich, 0.11 mL, 0.95 mmol). The title compound was obtained as a pale yellow oil (215 mg, 82%). HPLC, Rt: 6.1 min (purity: 94.5%). LC/MS, M+(ESI): 444.2. 1H NMR (CDCl3) δ: 7.51-7.44 (m, 4H), 7.32 (m, 3H), 7.17 (m, 3H), 6.92 (dd, J=9.8, 9.7 Hz, 1H), 6.74 (m, 1H), 4.49 (s, 2H), 3.88 (s, 3H), 3.35 (t, J=7.5 Hz, 2H), 1.61 (m, 2H), 1.29 (m, 6H), 0.88 (m, 3H).

Provenance & Evidence