Hydrochloric Acid → HCID 11585483, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 5-((cyclopentylmethyl){4-[(4-methoxyphenyl)ethynyl]-benzyl}amino)-2-hydroxybenzoate (200 mg; 0.43 mmol) was dissolved in THF (4 mL) and water (1.00 mL) was added LiOH (178 mg; 4.26 mmol). The mixture was then heated in MW for 2500 s at 100° C. It was poured into a 1N solution of HCl and extracted twice with EtOAc. The combined organic layers were dried over magnesium sulfate, filtered and concentrated to give 225 mg of a yellow oil. The oil was suspended in methanol and triturated to give 140 mg (72%) of the title compound as a yellow powder. Rt: 4.08 min (purity: 99.1%), LC/MS: M+(ESI): 456.0, M−(ESI): 454.2.

Provenance & Evidence