N-Methyl-D-glucamine → 5-[{4-[(4-butylphenyl)ethynyl]benzyl}(cyclopropylmethyl)amino]-2-fluorobenzoic acid N-methyl-D-glucamine

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Reaction Steps

The title compound was prepared following procedure described in example 24 from 5-[{4-[(4-butylphenyl)ethynyl]benzyl}(cyclopropylmethyl)amino]-2-fluorobenzoic acid (200 mg; 0.44 mmol) and N-methyl-D-glucamine (86 mg; 0.44 mmol) and obtained quantitatively as a brown powder. HPLC, Rt: 5.35 min purity: 98.7%), LC/MS, M−(ESI): 454.1. Analysis calculated for C30H30NO2F—C7H17−NO5-0.5 CH2Cl2-3.0 H20: calculated C, 60.27%, H, 7.28%, N, 3.75%; Found: C, 60.50%, H, 6.96%, N, 3.92%.

Provenance & Evidence