Propanal → Methyl 2-fluoro-5-{[4-(phenylethynyl)benzyl](propyl)-amino}benzoate

Participants

Reaction Steps

The title compound was prepared following the procedure described in Example 44 step a) using methyl 5-amino-2-fluorobenzoate (500 mg, 2.96 mmol), 4-(phenylethynyl)benzaldehyde (610 mg, 2.96 mmol) and propanal (Aldrich, 540 μL, 7.39 mmol). The title compound was obtained as a sticky colorless oil (628 mg, 53%). HPLC, Rt: 5.4 min (purity: 99.1%). LC/MS, M+(ESI): 402.2. 1H NMR (CDCl3) δ: 7.51-7.44 (m, 4H), 7.32 (m, 3H), 7.17 (m, 3H), 6.92 (dd, J=9.8, 9.6 Hz, 1H), 6.74 (m, 1H), 4.50 (s, 2H), 3.88 (s, 3H), 3.33 (t, J=7.3 Hz, 2H), 1.65 (m, 2H), 0.92 (t, J=7.5 Hz, 3H).

Provenance & Evidence