Hydrochloric Acid → 5-{{4-[(4-Butylphenyl)ethynyl]benzyl}[(2-carboxycyclopropyl) methyl]amino}-2-fluorobenzoic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 5-({4-[(4-butylphenyl)ethynyl]benzyl}{[2-(ethoxycarbonyl)cyclopropyl]methyl}amino)-2-fluorobenzoate (340 mg; 0.63 mmol) in anhydrous THF (5 mL) were added lithium hydroxide monohydrate (64 mg; 1.54 mmol) and water (7 mL). The reaction mixture was stirred under MW at 100° C. for 2500 s. Then an aqueous solution of HCl (1N) was added, the residue was extracted with EtOAc (2×100 mL). The combined organic layers were washed with brine (60 mL), dried over magnesium sulfate and the solvent was removed under reduced pressure to give 230 mg (73%) of the title compound as a white solid. HPLC, Rt: 4.99 min (purity 99.5%). LC/MS: M−(ESI): 498.2, 1H NMR (MeOD) δ: 7.46 (d, J=8.3 Hz, 2H), 7.41 (d, J=8.3 Hz, 2H), 7.29 (m, 3H), 7.21 (d, J=7.9 Hz, 2H), 4.66 (s, 2H), 3.44 (m, 1H), 2.65 (t, J=7.5 Hz, 2H), 1.65 (m, 3H), 1.35 (m, 3H), 1.15 (m, 1H), 0.95 (m, 4H), 3.59 (m, 1H), 7.05 (m, 2H).

Provenance & Evidence