反应详情

To a solution of 7-(dibromomethyl)-2,2-dimethyl-4H-1,3-benzodioxin-4-one (6.0 g, 17 mmol) in acetone (20 mL) and water (40 mL) under nitrogen was added AgNO3 (6.0 g, 35 mmol). The reaction mixture was stirred at rt for 14 hours, then filtered through a pad of Celite. The solvents were removed under reduced pressure. The residue was purified by chromatography (pet ether/EtOAc 9/1) to give 2.0 g (57%) of the titled compound as a solid. TLC-Pet Ether/EtOAc (7/3): Rf=0.7.

1. filtrationfiltered through a pad of Celite
2. customThe solvents were removed under reduced pressure
3. customThe residue was purified by chromatography (pet ether/EtOAc 9/1)