HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-Cyano-6-benzyloxymethyl quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzyl chloromethyl ether | HCID 137983 | — |
| Reactant | 6-Hydroxyquinoline-2-carbonitrile | HCID 14429534 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-Cyano-6-benzyloxymethyl quinoline | HCID 66838503 | — |
Reaction Steps
To a solution of 2-cyano-6-hydroxyquinoline (100 mg) in 10 mL of acetone was added potassium carbonate (122 mg). After stirring at RT for three minutes, the solution was put on ice. Benzyl chloromethyl ether (122 μL) was added through a needle and the resultant solution was stirred on ice for 2 hours. The solvent was then removed under vacuum and the residue was purified by flash chromatography with dichloromethane. 157 mg was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951550B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-5390042237a04690abb0a489ead1d619 |
| Source note | uspto-grants-2011_05 |