HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 135484607, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Olanzapine | HCID 135398745 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 135484607 | HCID 135484607 | 97.3% |
Reaction Steps
1 g (3.2 mmoles) of olanzapine base is dissolved in 20 cm3 of tetrahydrofuran by boiling in an apparatus equipped with a reflux condenser. Subsequently 3.4 g of hydrogen chloride solution in 1,4-dioxane (34.5 m/m %) are dropped to it. The mixture is cooled in ice-water for 10 minutes and the precipitated yellow product is filtered off. Thus 1.20 g (97%) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951798B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-6e7f45b06008470b8d3e88950344e50e |
| Source note | uspto-grants-2011_05 |