Hydrochloric Acid → HCID 135484607, compound

Participants

Reaction Steps

1 g (3.2 mmoles) of olanzapine base is dissolved in 25 cm3 of ethyl acetate by boiling in an apparatus equipped with a reflux condenser. Subsequently 8.5 cm3 of hydrogen chloride solution in ethyl acetate (13.7 g of hydrogen chloride in 100 cm3 of ethyl acetate) are dropped to it. The mixture is cooled in ice-water for 10 minutes and the yellow precipitated product is filtered off. Thus 1.20 g (97%) of the title compound is obtained.

Provenance & Evidence