HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → L-Valyl-L-valine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Boc-L-Valine | HCID 83693 | — |
| Reactant | HCID 178448382 | HCID 178448382 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | L-Valyl-L-valine | HCID 107475 | — |
Reaction Steps
Boc-VAL, DCC, DMF, 0° C., 1 hr, ii) DMAP, DMF, 18 hrs, rt iii) TFA, 0° C., 30 min, iv) Boc-Val, DCC, DMF, 0° C., 1 hr, v) TEA, rt, vi) adding Boc-Val amino acid anhydride (step iv) to the neutralized Val-ACV (step v), 5 hrs, rt, vii) TFA, 0° C., 30 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951774B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-17b1a54e57d1442fb549714abb81c98a |
| Source note | uspto-grants-2011_05 |