Hydrochloric Acid → 2-Aminopyrimidine-4-carbaldehyde

Participants

Reaction Steps

A solution of 2.5 g (15 mmol, 1.0 eq.) of 2-aminopyrimidine-4-carboxaldehyde dimethylacetal (I-8) in 16 mL (48 mmol, 3.2 eq.) of 3M HCl was heated at 48° C. for 14 h. The mixture was allowed to cool to room temperature and diluted with 50 mL of EtOAc. The aqueous layer was neutralized with NaHCO3 and then extracted with EtOAc (5×50 mL). The combined organic extracts were dried (Na2SO4) and the solvent removed in vacuo to provide 0.69 g (5.6 mmol, 37%) of 2-aminopyrimidine-4-carboxaldehyde (I-9) as a yellow solid.

Provenance & Evidence