HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenyl Isocyanate → HCID 58882012, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenyl Isocyanate | HCID 7693 | — |
| Reactant | (-)-2-Chloromandelic acid | HCID 2733641 | — |
| Catalyst | Di-n-butyldilauryltin | HCID 9809426 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58882012 | HCID 58882012 | 88.2% |
Reaction Steps
1 g (5 mmol) of (R)-(2-chlorophenyl)hydroxyacetic acid are dissolved in 10 ml of dichloromethane, and 0.77 g (5 mmol) of 4-chlorophenyl isocyanate and 50 mg of dibutyltin dilaurate are added successively, and the mixture is stirred for 16 hours. Conventional work-up gives 1.5 g of (R)-(2-chlorophenyl)(4-chlorophenylcarbamoyloxy)acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951804B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-a0b2b635fca0497a8047174171d70d40 |
| Source note | uspto-grants-2011_05 |