HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 67171766, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 4-Piperidinemethanol | HCID 420771 | — |
| Reactant | 6-Chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxamide | HCID 65561565 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 67171766 | HCID 67171766 | — |
Reaction Steps
To a stirred solution of 6-chloropyridazine-3-carboxylic acid (2-cyclopropylethyl)-amide (0.200 g, 0.90 mmol) in 1,4-dioxane (10 mL) was added 4-piperidine methanol (0.155 g, 1.40 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (0.4 mL, 2.700 mmol) and tetrabutyl ammonium bromide (0.032 g, 0.10 mmol). The resulting mixture was stirred at reflux for 18 hours. 1,4-Dioxane was removed in vacuo and the obtained crude product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951805B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-1da58eb7722547caa8e1929806a913ea |
| Source note | uspto-grants-2011_05 |