HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 11561097, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Piperidin-4-yl-(2-trifluoromethylphenyl)amine | HCID 54902682 | — |
| Reactant | 6-Chloro-N-(2-cyclopropylethyl)pyridazine-3-carboxamide | HCID 65561565 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 11561097 | HCID 11561097 | 57% |
Reaction Steps
A mixture of piperidin-4-yl-(2-trifluoromethylphenyl)amine (0.380 g, 1.55 mmol), 6-chloropyridazine-3-carboxylic acid (2-cyclopropylethyl)amide (0.276 g, 1.00 mmol), K2CO3 (0.277 g, 2.0 mmol) and n-Bu4NI (10 mg) in dioxane (10 mL) was heated to reflux overnight, then concentrated. The residue was purified by flash chromatography to give 6-[4-(2-trifluoromethylphenylamino)piperidin-1-yl]pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide (0.247 g). MS (ES+) m/z 434.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951805B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-3ae5445b121044cd986e5680b62d1618 |
| Source note | uspto-grants-2011_05 |