HCID 18072498, compound → HCID 11532719, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations only as required to use piperidine-4-carboxylic acid (2-trifluoromethylphenyl)amide in place of piperidin-4-yl-(2-trifluoromethylphenyl)amine to react with 6-chloropyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white powder in 89% yield. 1H NMR (300 MHz, CDCl3) δ 8.06 (d, J=7.9 Hz, 1H), 7.96 (d, J=9.4 Hz, 2H), 7.58-7.48 (m, 3H), 7.24-7.18 (m, 1H), 6.97 (d, J=9.5 Hz, 1H), 4.53-4.49 (m, 2H), 3.54-3.47 (m, 2H), 3.18-3.00 (m, 2H), 2.66-2.57 (m, 1H), 2.07-1.99 (m, 2H), 1.93-1.79 (m, 2H), 1.49-1.43 (m, 2H), 0.73-0.67 (m, 1H), 0.45-0.39 (m, 2H), 0.07-0.02 (m, 2H). 13C NMR (75 MHz, CDCl3) δ 172.4, 163.2, 159.9, 144.6, 134.9, 132.9, 126.9, 126.2, 126.1, 125.2, 124.9, 122.2, 112.2, 44.4, 43.8, 39.6, 34.5, 27.9, 43.8, 8.6, 4.2. MS (ES+) m/z 462 (M+1).

Provenance & Evidence