2-(Trifluoromethyl)benzoyl chloride → HCID 67172005, compound

Participants

Reaction Steps

Following the procedure as described in Example 4, making variations only as required to use 6-(4-aminopiperidin-1-yl)pyridazine-3-carboxylic acid (3-methylbutyl)amide to replace 6-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide to react with 2-trifluoromethylbenzoyl chloride, the title compound was obtained as a white powder in 29% yield. 1H NMR (300 MHz, CDCl3) δ 8.00 (d, J=9.5 Hz, 1H), 7.85 (t, J=5.6 Hz, 1H), 7.70 (d, J=7.5 Hz, 1H), 7.52-7.61 (m, 3H), 7.01 (d, J=9.6 Hz, 1H), 5.71 (d, J=7.9 Hz, 1H), 4.49 (d, J=13.7 Hz, 2H), 4.30-4.38 (m, 1H), 3.49 (dd, J=6.6 and 13.7 Hz, 2H), 3.22-3.27 (m, 2H), 2.20-2.23 (m, 2H), 1.48-1.76 (m, 5H), 0.94 (d, J=6.6 Hz, 6H). MS (ES+) m/z 463.9 (M+1).

Provenance & Evidence