Ammonium Acetate → N-(6-chloro-7-cyclopropylmethoxy-9H-beta-carbolin-8-yl)-2-methyl-nicotinamide

Participants

Reaction Steps

The desired compound was prepared according to Method A from 6-chloro-7-cyclopropylmethoxy-9H-β-carbolin-8-ylamine and 2-methylnicotinic acid in a 40-60% yield. 1H-NMR (300 MHz, MeOH-d4): 60.29 (m, 2H), 0.55 (m, 2H), 1.29 (m, 1H), 2.78 (s, 3H), 3.95 (m, 2H), 7.46 (dd, 1H), 8.08 (m, 1H), 8.30 (m, 3H), 8.59 (m, 1H), 8.81 (s, 1H). Retention Time (LC, method: ammonium acetate standard): 2.18 min. MS (M+H+): 405.

Provenance & Evidence