2,3,4,9-Tetrahydro-4-methyl-1H-pyrido[3,4-b]indole → 4-Methyl-9H-beta-carboline

Participants

Reaction Conditions

Reaction Steps

4-methyl-2,3,4,9-tetrahydro-1H-β-carboline (214 mg, 1.17 mmol) was suspended in xylenes (10 ml). Pd (10% wt. on carbon, 21 mg) catalyst was added thereto and the reaction mixture was stirred at 160° C. for 24 hours, then cooled to RT and filtered through celite. The filtrate was concentrated to dryness to give 4-methyl-9H-β-carboline (210 mg). 1H-NMR (300 MHz, DMSO-d6): δ 11.73 (br s, 1); 8.78 (br s, 1); 8.19 (d, 1); 8.13 (s, 1); 7.62 (br s, 1); 7.53 (t, 1); 7.25 (t, 1); 2.78 (s, 3). NH4OAc standard conditions. DAD Rf=2.24 min. M+H=183.

Provenance & Evidence