Ammonium Acetate → (S)-6,6-Dimethyl-4-((S)-2-[(2-methyl-pyridine-3-carbonyl)amino]propyl)-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide

Participants

Reaction Steps

The desired compound was prepared according to Method E from (S)-4-((S)-2-Amino-propyl)-6,6-dimethyl-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide trifluoroacetate salt and 2-methyl-nicotinic acid in 75% yield. 1H-NMR (300 MHz, DMSO-d6): δ 1.21 (s,3H), 1.22 (d,3H), 1.36 (s,3H), 2.10 (d,1H), 2.42 (m,1H), 2.60 (m,1H), 2.99 (d,1H), 3.20 (m,1H), 3.92 (m,2H), 4.22 (m,1H), 7.22 (dd,1H), 7.65 (d,1H), 7.90 (s,1H), 8.16 (d,1H), 8.23 (s,1H), 8.31 (d,1H), 8.38 (d,1H), 8.45 (d,1H), 9.02 (s,1H), 10.04 (s,1H), 11.26 (s,1H). Retention Time (LC, method: ammonium acetate standard): 2.16 min. MS (M+H+): 535.5.

Provenance & Evidence