Ammonium Acetate → 6,6-Dimethyl-4-{3-methyl-2-(S)-[(tetrahydro-furan-3-carbonyl)-amino]-butyl}-morpholine-3-(S)-carboxylic acid (6-chloro-9H-b-carbolin-8-yl)-amide

Participants

Reaction Steps

The desired compound was prepared following Method E from Intermediate 61 and the appropriate acid. 1H-NMR (300 MHz, methyl-d3 alcohol-d): δ 0.87 (m, 6H), 1.25 (d, 3H), 1.37 (d, 3H), 1.81 (m, 1H), 2.10-2.47 (m, 4H), 2.93 (m, 2H), 3.10 (m, 1H), 3.26 (m, 1H), 3.80 (m, 1H), 3.86-4.07 (m, 6H), 7.86 (d, 1H), 8.10 (m, 2H), 8.32 (d, 1H), 8.89 (s, 1H). Retention Time (LC, method: ammonium acetate standard): 1.73 min. MS (M+H+): 542.

Provenance & Evidence