Morpholine → (S)-6,6-Dimethyl-4-(2-morpholin-4-yl-2-oxo-ethyl)-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide

Participants

Reaction Steps

The desired compound was prepared according to Method F from [(S)-5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acid and morpholine in 86% yield. 1H-NMR (300 MHz, DMSO-d6): δ 1.17 (s,3H), 1.30 (s,3H), 2.19 (d,1H), 2.71 (d,1H), 3.03 (d,1H), 3.16 (d,1H), 3.22 (dd,1H), 3.45-3.72 (m,7H), 3.80-3.98 (m, 3H), 7.94 (d,1H), 8.15 (d,1H), 8.21 (d,1H), 8.37 (d,1H), 9.03 (s,1H), 10.35 (s,1H), 11.28 (s,1H). Retention Time (LC, method: ammonium acetate standard): 1.56 min. MS (M+H+): 486.3.

Provenance & Evidence