HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → N-[4-(4H-Pyrazolo[5,1-c][1,4]benzodiazepin-5(10H)-ylcarbonyl)-3-chlorophenyl]-2-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-[(2-Methylbenzoyl)amino]2-chlorobenzoyl chloride | HCID 10566710 | — |
| Reactant | 5,10-dihydro-4H-pyrazolo[5,1-c][1,4]benzodiazepine | HCID 13062825 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[4-(4H-Pyrazolo[5,1-c][1,4]benzodiazepin-5(10H)-ylcarbonyl)-3-chlorophenyl]-2-methylbenzamide | HCID 21837051 | — |
Reaction Steps
As described for Example 518, a mixture of 0.185 g of 5,10-dihydro-4H-pyrazolo[5,1-c][1,4]benzodiazepine, 0.369 g of 4-[(2-methylbenzoyl)amino]-2-chlorobenzoyl chloride and 0.158 g of diisopropylethylamine in 10 ml of dichloromethane is stirred at room temperature to give crystals (from ethyl acetate) m.p. 241°-244° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624923 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-3a16fd2150d44957874a8b05ce93b2c5 |
| Source note | uspto-grants-1997_04 |