HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 552301Generated: October 30, 2026
2-Ethylphenylboronic Acid (contains varying amounts of Anhydride) → HCID 59248984, compound
https://huagongshe.com/reaction/552301
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Ethylphenylboronic Acid (contains varying amounts of Anhydride) | HCID 4100862 | — |
| Reactant | HCID 67165156 | HCID 67165156 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 59248984 | HCID 59248984 | — |
Reaction Steps
1-(4-Bronno-5-ethyl-thiophen-2-yl)-3-(4-hydroxy-3,5-dimethyl-phenyl)-propan-1-one (45 mg, 123 μmol) and 2-ethylphenylboronic acid (22 mg, 148 μmol) are dissolved in degassed dioxane (0.8 mL) and degassed 2 M aq. Na2CO3 solution. To this solution PdCl2(dppf) (5 mg, 7 μmol) is added under a stream of argon. The mixture is stirred at 80° C. for 8 h. The mixture is cooled to rt and an aliquot is purified by prep. HPLC to give 1-[5-ethyl-4-(2-ethyl-phenyl)-thiophen-2-yl]-3-(4-hydroxy-3,5-dimethyl-phenyl)-propan-1-one as a colourless resin; LC-MS: tR=1.10 min, [M+1]+=383.25.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07951794B2 |
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| Source dataset | uspto-grants-2011_05 |
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| ORD ID | ord-74389270d77d4f0383c56e39a1639fa0 |
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| Source note | uspto-grants-2011_05 |
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