反应详情

0.38 ml (3.1 mmol) chloroformic acid ethyl ester were added to 0.8 g (2.8 mmol) of the intermediate product 3b in 20 ml pyridine at 0° C., and then everything was stirred for 16 h at room temperature. Then the batch was poured on to icy water and extracted with ethyl acetate. The organic phase was washed with water, dried and concentrated in a vacuum. The residue obtained in this way was dissolved in a little ether and the product was precipitated by the careful addition of n-pentane. 1.1 g were obtained.

1. extractionextracted with ethyl acetate
2. washThe organic phase was washed with water
3. customdried
4. concentrationconcentrated in a vacuum
5. customThe residue obtained in this way
6. customthe product was precipitated by the careful addition of n-pentane
7. custom1.1 g were obtained