HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 8-(2,4-dimethoxybenzoyl)-3-(S)-(2-methylsulfanylethyl)-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | HCID 67165786 | HCID 67165786 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 8-(2,4-dimethoxybenzoyl)-3-(S)-(2-methylsulfanylethyl)-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride | HCID 67165785 | — |
Reaction Steps
8-(2,4-Dimethoxybenzoyl)-3-(S)-(2-methylsulfanylethyl)-1,4,8-triazaspiro[4,5]decan-2-one (300 mg, 0.8 mmol) was dissolved in ethyl methyl ketone (2 ml), treated with water (8 μL) and TMSCl (106 μL) and stirred overnight. The solid was filtered off and dried in vacuo. The product 8-(2,4-dimethoxybenzoyl)-3-(S)-(2-methylsulfanylethyl)-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 320 mg (97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951815B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-412afaf238d74eb689ca161ea6391f68 |
| Source note | uspto-grants-2011_05 |