Water → HCID 67166148, compound

HRID 552333Notes

Reaction equation

HRID 552333 reaction equation
[C:1]([N:4]1[CH2:21][CH2:20][C:7]2([NH:11][C:10](=[O:12])[C@H:9]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:8]2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].O.C[Si]([Cl:27])(C)C>CC(CC)=O>[ClH:27].[C:1]([N:4]1[CH2:5][CH2:6][C:7]2([NH:11][C:10](=[O:12])[C@H:9]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:8]2)[CH2:20][CH2:21]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 67166149HCID 67166149, compound

Product 1

HCID 67166148HCID 67166148, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

8-Acetyl-3-(S)-benzyl-1,4,8-triazaspiro[4,5]decan-2-one (300 mg, 1.0 mmol) was dissolved in ethyl methyl ketone (2 ml), treated with water (21 μL) and TMSCl (290 μL) and stirred overnight. The solid precipitated in this process was filtered off, washed with ether and dried in vacuo. The product 8-acetyl-3-(S)-benzyl-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 330 mg (96%).

Workup

  1. customThe solid precipitated in this process
  2. filtrationwas filtered off
  3. washwashed with ether
  4. customdried in vacuo

Sources & evidence

ORD record
ord-89347e820dee4ebb925a917e97995dbd
Source dataset
uspto-grants-2011_05
Patent number
US07951815B2

Reaction notes

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