Water → HCID 67165923, compound

Participants

Reaction Steps

3-(S)-benzyl-8-(4-chlorobenzoyl)-1,4,8-triazaspiro[4,5-]-decan-2-one (500 mg, 1.3 mmol) was dissolved in ethyl methyl ketone (4 mL), and water (13 μL) and TMSCl (181 μL) were added and the mixture was stirred overnight. The precipitated solid matter was isolated by filtration, washed with ether, and dried in vacuo. The product 3-(S)-benzyl-8-(4-chlorobenzoyl)-1,4,8-triazaspiro[4,5-]-decan-2-one hydrochloride was obtained in a yield of 390 mg (72%).

Provenance & Evidence