Water → HCID 67165600, compound

Participants

Reaction Steps

1,3-(S)-dibenzyl-8-(2-ethylbutyryl)-1,4,8-triazaspiro[4,5]decan-2-one (654 mg, 1.5 mmol) was dissolved in ethyl methyl ketone (5 mL), and water (15 μL) and TMSCl (210 μL) were added and the mixture was stirred overnight. Hexane (10 mL) was then added. The precipitated solid matter was isolated by filtration and dried in vacuo. The product 1,3-(S)-dibenzyl-8-(2-ethylbutyryl)-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 671 mg (95%).

Provenance & Evidence