Water → HCID 67165684, compound

Participants

Reaction Steps

1,3-(S)-dibenzyl-8-(4-chlorobenzoyl)-1,4,8-triazaspiro[4,5]decan-2-one (2.6 g, 5.5 mmol) was dissolved in ethyl methyl ketone (21 mL), and water (54 μL) and TMSCl (763 μL) were added and the mixture was stirred overnight. Hexane (10 mL) was then added, and the solid matter was isolated by filtration and dried in vacuo. The precipitated solid matter was isolated by filtration and dried in vacuo. The product 1,3-(S)-dibenzyl-8-(4-chlorobenzoyl)-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 2.53 g (90%). Examples 35 and 36 were prepared with irradiation by microwaves:

Provenance & Evidence