Water → HCID 67165364, compound

HRID 552351Notes

Reaction equation

HRID 552351 reaction equation
[CH2:1]([N:8]1[C:12]2([CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[NH:11][C@@H:10]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:9]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.C[Si]([Cl:31])(C)C>CC(CC)=O>[ClH:31].[CH2:1]([N:8]1[C:12]2([CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)[NH:11][C@@H:10]([CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:9]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 67165365HCID 67165365, compound

Product 1

HCID 67165364HCID 67165364, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

1,3-(S)-Dibenzyl-1,4,8-triazaspiro[4,5]decan-2-one (400 mg, 1.2 mmol) was dissolved in ethyl methyl ketone (3 ml), treated with water (12 μL) and with TMSCl (166 μL) and stirred overnight. The solid was filtered off, washed with ether and dried in vacuo. The product 1,3-(S)-dibenzyl-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 315 mg (71%).

Workup

  1. filtrationThe solid was filtered off
  2. washwashed with ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-9da8c48ea08f4ce39e0f7a101ea07aea
Source dataset
uspto-grants-2011_05
Patent number
US07951815B2

Reaction notes

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