Water → HCID 67165180, compound

HRID 552353Notes

Reaction equation

HRID 552353 reaction equation
[CH2:1]([N:8]1[C:12]2([CH2:17][CH2:16][N:15]([C:18](=[O:22])[CH2:19][CH2:20][CH3:21])[CH2:14][CH2:13]2)[NH:11][C@@H:10]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:9]1=[O:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.C[Si]([Cl:36])(C)C>CC(CC)=O>[ClH:36].[CH2:1]([N:8]1[C:12]2([CH2:17][CH2:16][N:15]([C:18](=[O:22])[CH2:19][CH2:20][CH3:21])[CH2:14][CH2:13]2)[NH:11][C@@H:10]([CH2:23][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:9]1=[O:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 67165181HCID 67165181, compound

Product 1

HCID 67165180HCID 67165180, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

1,3-(S)-dibenzyl-8-butyryl-1,4,8-triazaspiro[4,5]decan-2-one (272 mg, 10.7 mmol) was dissolved in ethyl methyl ketone (2.2 mL), and water (7 μL) and TMSCl (93 μL) were added and the mixture was stirred overnight. The solid matter was isolated by filtration, washed with ether, and dried in vacuo. The product 1,3-(S)-dibenzyl-8-butyryl-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 281 mg (95%).

Workup

  1. customThe solid matter was isolated by filtration
  2. washwashed with ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-84a496de52bc47f2bd41a1a58f467ab2
Source dataset
uspto-grants-2011_05
Patent number
US07951815B2

Reaction notes

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