Water → HCID 67170364, compound

Participants

Reaction Steps

1,3-(S)-dibenzyl-8-(naphthalin-2-carbonyl)-1,4,8-triazaspiro[4,5]decan-2-one (400 mg, 0.8 mmol) was dissolved in ethyl methyl ketone (3.2 mL), water (8 μL), TMSCl (114 μL), and ether (20 mL) were added and the mixture was stirred overnight. The solid matter was isolated by filtration, washed with ether, and dried in vacuo. The product 1,3-(S)-dibenzyl-8-(naphthalin-2-carbonyl)-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 407 mg (95%).

Provenance & Evidence