Water → HCID 67167255, compound

Participants

Reaction Steps

1,3-(S)-dibenzyl-8-(3-methoxybenzoyl)-1,4,8-triazaspiro[4,5]decan-2-one (404 mg, 0.9 mmol) was dissolved in ethyl methyl ketone (3.2 mL), and water (9 μL) and TMSCl (120 μL) were added and the mixture was stirred overnight. The solid matter was isolated by filtration, washed with ether, and dried in vacuo. The product 1,3-(S)-dibenzyl-8-(3-methoxybenzoyl)-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 358 mg (82%).

Provenance & Evidence