Water → HCID 67166848, compound

Participants

Reaction Steps

1-benzyl-8-(4-fluorobenzoyl)-3-(S)-(2-methylsulfanylethyl)-1,4,8-triazaspiro[4,5]decan-2-one (223 mg, 0.5 mmol) was dissolved in ethyl methyl ketone (1.8 mL), water (5 μL) and TMSCl (70 μL) were added and the mixture was stirred overnight. The solid matter was isolated by filtration, washed with ether, and dried in vacuo. The product 1-benzyl-8-(4-fluorobenzoyl)-3-(S)-(2-methylsulfanylethyl)-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 227 mg (94%).

Provenance & Evidence