Triethylamine → HCID 67165236, compound

Participants

Reaction Steps

To a solution of Step 4 intermediate (1.28 g, 6.33 mmol) in dry DMF (6.3 ml) was added triethylamine (4.38 ml, 31.35 mmol) and ethyl chloroformate (3.03 ml, 31.65 mmol). The reaction was stirred at room temperature for 24 h. The reaction was diluted with water, extracted with ethyl acetate, washed with brine and dried over Na2SO4. Purification of the crude product by silica gel column chromatography using 1% ethyl acetate in chloroform afforded 1.3 g of the title compound; 1H NMR (δ ppm, CDCl3, 300 MHz): 9.56 (br.s, 1H); 7.49 (t, J=7.8, 1H); 7.05 (d, J=7.2, 1H); 6.93 (d, J=8.4, 1H); 6.11-5.90 (m, 1H), 5.07-4.98 (m, 2H); 4.53 (q, J=7.2, 2H); 3.96 (d, J=6.3, 2H); 1.46 (t, J=7.2, 3H).

Provenance & Evidence