Triethylamine → HCID 67120781, compound

Participants

Reaction Steps

To a solution of 2,6-diaminopyridine (10 g, 91.743 mmol) and triethylamine (11.14 g, 110.091 mmol, 1.2 equiv.) in DCM (100 mL) at 0° C. is added dropwise a solution of pivaloyl chloride (12.11 g, 100.917 mmol, 1.1 equiv.) in DCM (50 mL) over 2 hours. After completion of the addition the mixture is allowed to warm to room temperature over 30 minutes, at which point LC-MS shows full conversion to the desired material. The mixture is filtered to remove the triethylammonium chloride, and the solvent is removed under vacuum to afford a solid that is not processed further.

Provenance & Evidence