HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 552396Generated: October 31, 2026
Lithium hydroxide, monohydrate → HCID 57580671, compound
https://huagongshe.com/reaction/552396
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | 4-(5-Chloro-imidazo[1,2-a]pyridin-8-ylamino)-benzoic acid methyl ester | HCID 57580722 | — |
| Reactant | (5-Chloro-imidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropyl-piperazin-1-yl)-phenyl]-amine | HCID 57580808 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | HCID 57580671 | HCID 57580671 | — |
Reaction Steps
A mixture of 4-(5-chloro-imidazo[1,2-a]pyridin-8-ylamino)-benzoic acid methyl ester (450 mg, 1.495 mmol), prepared using methods similar to those described for compound 12, step 1, and lithium hydroxide hydrate (250.9 mg, 5.98 mmol) in solution in dioxane/water (2/1: 30 mL) is heated at 60° C. for 2 hours. The mixture is concentrated and then acidified to pH 1 with aqueous 2N HCl. The resulting precipitate is filtrated to yield the title compound, which is used as such for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07951818B2 |
|---|
| Source dataset | uspto-grants-2011_05 |
|---|
| ORD ID | ord-7288dddfc6f74019b2aaa1b4dc75c6c7 |
|---|
| Source note | uspto-grants-2011_05 |
|---|
