HCID 45140537, compound → HCID 45140734, compound

Participants

Reaction Steps

Method D was used with N-(3-(2-Amino-3-nitropyridin-4-yloxy)-5-chlorophenyl)-3-(trifluoromethoxy)benzamide and with 5% sulphided platinum on carbon as catalyst to afford the title compound (92 mg, 98%). 1H NMR δ (DMSO) 4.53 (s, 2H, NH2), 5.66 (s, 2H, NH2), 6.19 (d, 1H, Hpy,5, J=5.5 Hz), 6.82 (t, 1H, Harom, J=2 Hz), 7.31 (d, 1H, Hpy,6, J=5.5 Hz), 7.34 (t, 1H, Harom, J=2 Hz), 7.61 (d, 1H, Harom, J=8 Hz), 7.68 (t, 1H, Harom, J=8 Hz), 7.73 (t, 1H, Harom, J=2 Hz), 7.87 (s, 1H, Harom,2′), 7.97 (d, 1H, Harom, J=8 Hz), 10.51 (s, 1H, CONH). 19F NMR δ (DMSO)-56.37 (s, 3F, CF3). MS m/z 439/441 (M++1).

Provenance & Evidence