反应详情

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 3-bromo-benzoyl chloride to afford the title compound as a light brown solid (50 mg, 73%). 1H-NMR (δ, ppm, DMSO-d6): 6.50 (d, 1H, HPy,5, J=6.0 Hz), 6.92 (d, 1H, Harom, J=8.0 Hz), 7.43 (ps t, 1H, Harom, J=8.0 Hz), 7.48 (m, 1H, Harom), 7.62 (s, 1H, Harom), 7.66 (d, 1H, Harom, J=8.0 Hz), 7.78-7.84 (m, 2H, Harom+Py,6), 7.93 (d, 1H, Harom, J=8.0 Hz), 8.12 (s, 1H, Harom), 10.45 (s, 1H, NHamide), 11.23 (s, 1H, NHPy3), 11.44 (s, 1H, NHPy2). 13C-NMR (δ, ppm, DMSO-d6): 106.58, 110.82, 113.83, 114.62, 116.32, 121.66, 126.87, 128.24, 130.65, 130.87, 131.71, 136.80, 140.56, 141.08, 144.67, 147.00, 154.17, 154.68, 164.13. HRMS (EI): m/z [M+H] calcd for C19H14BrN4O3: 425.0249; found: 425.0248.