4-Fluoro-3-(trifluoromethoxy)benzoyl chloride → HCID 45141561, compound

Participants

Reaction Steps

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 4-fluoro-3-(trifluoromethoxy)benzoyl chloride to afford the title compound as a brown solid (25 mg, 43%). 1H-NMR (δ, ppm, DMSO-d6): 6.49 (d, 1H, HPy,5, J=6.0 Hz), 6.93 (d, 1H, Harom, J=8.0 Hz), 7.44 (t, 1H, Harom, J=8.0 Hz), 7.59 (s, 1H, Harom), 7.63 (d, 1H, Harom, J=9.0 Hz), 7.70 (t, 1H, Harom, J=9.0 Hz), 7.81 (d, 1H, HPy,6, J=6.0 Hz), 8-06-8.13 (m, 2H, Harom), 10.47 (s, 1H, NHamide), 11.20 (s, 1H, NHPy3), 11.39 (s, 1H, NHPy2).

Provenance & Evidence