4-(Trifluoromethyl)benzoyl chloride → HCID 45141110, compound

Participants

Reaction Steps

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 4-(trifluoromethyl)benzoyl chloride to afford the title compound as a brown solid (33 mg, 61%). 1H-NMR (δ, ppm, DMSO-d6): 6.50 (d, 1H, HPy,5, J=6.0 Hz), 6.93 (d, 1H, Harom, J=7.0 Hz), 7.44 (t, 1H, Harom, J=8.0 Hz), 7.63 (s, 1H, Harom), 7.64-7.68 (m, 1H, Harom), 7.82 (d, 1H, HPy,6, J=6.0 Hz), 7.91 (d, 2H, Harom, J=8.0 Hz), 8.12 (d, 2H, Harom, J=8.0 Hz), 10.55 (s, 1H, NHamide), 11.20 (s, 1H, NHPy3), 11.38 (s, 1H, NHPy2).

Provenance & Evidence