1-Phenyl-1H-pyrazole-5-carbonyl chloride → HCID 45142204, compound

Participants

Reaction Steps

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 1-phenyl-1H-pyrazole-5-carbonyl chloride to afford the title compound (15 mg, 17%). 1H-NMR (δ, ppm, DMSO-d6): 6.47 (d, 1H, HPy,5, J=6.0 Hz), 6.89 (d, 1H, Harom, J=8.0 Hz), 7.06 (d, 1H, Hpyrrazole, J=2.1 Hz), 7.37-7.49 (m, 7H, Harom), 7.53 (d, 1H, Harom, J=8.0 Hz), 7.78-7.81 (m, 2H, Hpyrrazole+Py,6), 10.64 (s, 1H, NHamide), 11.16 (s, 1H, NHPy3), 11.37 (s, 1H, NHPy2). HRMS (EI): m/z [M+H] calcd for C22H17N6O3: 413.1362; found: 413.1366.

Provenance & Evidence