1-benzyl-3-tert-butyl-1H-pyrazole-5-carbonyl chloride → HCID 45142431, compound

Participants

Reaction Steps

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and 1-benzyl-3-tert-butyl-1H-pyrazole-5-carbonyl chloride to afford the title compound (40 mg, 39%). 1H-NMR (δ, ppm, DMSO-d6): 1.29 (s, 9H, t-Bu), 5.67 (s, 2H, CH2), 6.47 (d, 1H, HPy,5, J=6.0 Hz), 6.89 (d, 1H, Harom, J=8.0 Hz), 7.00 (s, 1H, Hpyrrazole), 7.11 (d, 2H, Harom, J=8.0 Hz), 7.22 (t, 1H, Harom, J=7.0 Hz), 7.11 (t, 2H, Harom, J=8.0 Hz), 7.40 (t, 1H, Harom, J=8.0 Hz), 7.48-7.51 (m, 1H, Harom), 7.60 (d, 1H, Harom, J=8.0 Hz), 7.79 (d, 1H, HPy,6, J=6.0 Hz), 10.23 (s, 1H, NHamide), 11.18 (s, 1H, NHPy3), 11.38 (s, 1H, NHPy2). HRMS (EI): m/z [M+H] calcd for C27H27N6O3: 483.2145; found: 483.2145.

Provenance & Evidence