1-benzothiophene-5-carbonyl chloride → HCID 45141967, compound

Participants

Reaction Steps

Method H was used with 7-(3-aminophenoxy)-1H-imidazo[4,5-b]pyridin-2(3H)-one and benzo[b]thiophene-5-carbonyl chloride to afford the title compound (25 mg, 30%). 1H-NMR (δ, ppm, DMSO-d6): 6.50 (d, 1H, HPy,5, J=6.0 Hz), 6.91 (d, 1H, Harom, J=7.0 Hz), 7.43 (t, 1H, Harom, J=8.0 Hz), 7.60 (d, 1H, Harom, J=5.0 Hz), 7.67 (t, 1H, Harom, J=2.5 Hz), 7.81 (d, 1H, HPy,6, J=6.0 Hz), 7.89 (d, 1H, Harom, J=6.0 Hz), 7.91 (d, 1H, Harom, J=8.0 Hz), 8.15 (d, 1H, Harom, J=8.5 Hz), 8.49 (d, 1H, Harom, J=1.5 Hz), 10.44 (s, 1H, NHamide), 11.20 (s, 1H, NHPy3), 11.39 (s, 1H, NHPy2). HRMS (EI): m/z [M+H] calcd for C21H15N4O3: 403.0865; found: 403.0867.

Provenance & Evidence